publicaciones

IRTGroup:

• García-González P, Schinnerling K, Sepúlveda-Gutiérrez A, Maggi J, Mehdi AM, Nel HJ, Pesce B, Larrondo M, Aravena O, Molina MC, Catalán D, Thomas R, Verdugo R, Aguillón JC. Dexamethasone and monophosphoryl lipid A induce a distinctive profile on monocyte-derived dendritic cells through transcriptional modulation of genes associated with essential processes of the immune response. Frontiers in Immunology. 2017 Oct 23;8:1350.

• Schinnerling K, Aguillón JC, Catalán D, Soto L. The role of IL-6 signaling and its therapeutic blockage in skewing the T cell balance in rheumatoid arthriti. Clinical and Experimental Immunology. 2017 Apr 1.

• Aravena O, Ferrier A, Menon M, Mauri C, Aguillón JC, Soto L, Catalán D. TIM-1 defines a human regulatory B cell population that is altered in frequency and function in systemic sclerosis patients. Arthritis Research & Therapy. 2017;19(1):8.

• García-González P, Schinnerling K, Sepúlveda-Gutiérrez A, Maggi J, Hoyos L, Morales R, Medhi AM, Nel HJ, Soto L, Pesce B, Molina MC, Cuchacovich M, Larrondo M, Neira O, Catalán D, Hilkens C, Thomas R, Verdugo R, Aguillón JC. Treatment with dexamethasone and monophosphoryl lipid A removes disease-associated transcriptional signatures in monocyte-derived dendritic cells from rheumatoid arthritis patients and confers tolerogenic features. Frontiers in Immunology. 2016. ISSN: 1664-3224.

• Maggi J, Schinnerling K, Pesce B, Hilkens CM, Catalán D, Aguillón JC. Dexamethasone and monophosphoryl lipid A-modulated dendritic cells promote antigen-specific tolerogenic properties on naive and memory CD4+ T cells. Frontiers in Immunology. 2016; 7: 359.

• García-González P, Ubilla-Olguín G, Catalán D, Schinnerling K, Aguillón JC. Tolerogenic dendritic cells for reprogramming of lymphocyte responses in autoimmune diseases. Autoimmunity Reviews. 2016; 15: 1071-1080.

• Schinnerling K, García-González P, Aguillón JC. Gene Expression Profiling of Human Monocyte-derived Dendritic Cells - Searching for Molecular Regulators of Tolerogenicity. Front Immunol. 2015 Oct 19;6:528. IF: 5.695

• Soto L, Catalán D, Aguillón JC, Cuchacovich M. How we can improve the predictive value of prognostic biomarkers in rheumatoid arthritis. International Journal of Clinical Rheumatology. 10 (4):00-00. 2015.

• Soto L, Ferrier A, Aravena O, Fonseca E, Berendsen J, Biere A, Bueno D, Ramos V, Aguillón JC, Catalán D. Systemic sclerosis patients present alterations in the expression of molecules involved in B-cell regulation. Frontiers in Immunology. 6:496. 2015.

• Maggi J, Schafer C, Ubilla-Olguín G, Catalán D, Schinnerling K, Aguillón JC. Therapeutic potential of hyporesponsive CD4+ T cells in autoimmunity. Frontiers in Immunology. 6:488. 2015.

• Schinnerling K, Soto L, García-González P, Catalán D, Aguillón JC. Skewing dendritic cell differentiation towards a tolerogenic state for recovery of tolerance in rheumatoid arthritis. Autoimmun Rev. 2015; Jan 26.

• Cuchacovich M, Bueno D, Carvajal R, Bravo N, Aguillón JC, Catalán D, Soto L. Clinical parameters and biomarkers for anti-TNF treatment prognosis in rheumatoid arthritis patients. Clin Rheumatol. 2014;33(12):1707-14.

• Escobar A, Aguirre A, Guzmán MA, González R, Catalán D, Acuña-Castillo C, Larrondo M, López M, Pesce B, Rolland J, O`Hehir R, Aguillón JC. Tolerogenic dendritic cells derived from donors with natural rubber latex allergy modulate allergen-specific T-cell responses and IgE production. PLoS One. 2014. e85930.

• Peña C, Gárate D, Contreras-Levicoy J, Aravena O, Catalán D, Aguillón JC. Dexamethasone preconditioning improves the response of collagen-induced arthritis to treatment with short-term lipopolysaccharide-stimulated collagen-loaded dendritic cells. Clin Dev Immunol. 2013; 2013:296031.

• García-González P, Morales R, Hoyos L, Maggi J, Campos J, Pesce B, Gárate D, Larrondo M, González R, Soto L, Ramos V, Tobar P, Molina MC, Pino-Lagos K, Catalán D, Aguillón JC. A short protocol using dexamethasone and monophosphoryl lipid A generates tolerogenic dendritic cells that display a potent migratory capacity to lymphoid chemokines. J Transl Med. 2013;11:128.

• Pesce B, Soto L, Sabugo F, Wurmann P, Cuchacovich M, López MN, Sotelo PH, Molina MC, Aguillón JC, Catalán D. Effect of interleukin-6 receptor blockade on the balance between regulatory T cells and T helper type 17 cells in rheumatoid arthritis patients. Clin Exp Immunol. 2013;171(3):237-42.

• Gárate D, Rojas-Colonelli N, Peña C, Salazar L, Abello P, Pesce B, Aravena O, García-González P, Ribeiro CH, Molina MC, Catalán D, Aguillón JC. Blocking of p38 and transforming growth factor β receptor pathways impairs the ability of tolerogenic dendritic cells to suppress murine arthritis. Arthritis Rheum. 2013;65(1):120-9.

Laboratorio Dra  F. Osorio:

• Osorio F*, Lambrecht B and Janssens S*. 2018. Antigen presentation unfolded: identifying convergence points between the UPR and antigen presentation pathways. Current Opinion in Immunology 2018, 52: 100-107.* corresponding author. 

• Tavernier SJ*, Osorio F*, Vandersarren L, Vetters J, Vanlangenakker N, Van Isterdael G, Vergote K, Parthoens E, van de Laar L, Iwawaki T, Del Valle JR, Hu A, Lambrecht BN and Janssens S “Regulated Inositol-Requiring Enzyme 1 dependent mRNA decay sets the threshold for dendritic cell survival”. Nature Cell Biology 2017. 19, 698-710. doi:10.1038/ncb3518.* co-first author

• Osorio F*, Fuentes C, López MN, Salazar-Onfray F, González FE*. 2015. Role of Dendritic Cells in the Induction of Lymphocyte Tolerance. Frontiers in immunology. Oct 20; 6:535.* corresponding author

• Osorio F, Tavernier S, Hoffmann E, Saeys Y, Vetters J, Delrue I, De Rycke R, Parthoens E, Poulliot P, Iwawaki T, Janssens S and Lambrecht B.N. 2014. The unfolded-protein-response sensor IRE-1α regulates the function of CD8α+ dendritic cells. Nature Immunology 15 (3): 248-257.

• Osorio F, Lambrecht BN and Janssens S. 2013. The UPR and lung disease. Seminars in Immunopathology. 35(3) 293-306.

Laboratorio Dr R. Naves:

• Olivares-Morales MJ, De La Fuente MK, Dubois-Camacho K, Parada D, Diaz-Jiménez D, Torres-Riquelme A, Xu X, Chamorro-Veloso N, Naves R, Gonzalez MJ, Quera R, Figueroa C, Cidlowski JA, Vidal RM, Hermoso MA.
  “GLUCOCORTICOIDS IMPAIR PHAGOCYTOSIS AND INFLAMMATORY RESPONSE AGAINST CROHN'S DISEASE-ASSOCIATED ADHERENT-INVASIVE ESCHERICHIA COLI”.
  Frontiers in Immunology. 9: 1026. 2018

• Gabriel Arellano, Eric Acuña, Lilian Reyes, Payton A. Ottum, Patrizia De Sarno, Luis Villarroel, Ethel Ciampi, Reinaldo Uribe-San Martín, Claudia Cárcamo and Rodrigo Naves*.
  “Th1 AND Th17 CELLS AND ASSOCIATED CYTOKINES DISCRIMINATE AMONG CLINICALLY ISOLATED SYNDROME AND MULTIPLE SCLEROSIS PHENOTYPES”.
  Frontiers in Immunology. 8: 753. 2017

• Evelyn Pardo, Reinaldo Uribe-San Martín, Claudia Cárcamo, Ethel Ciampi, Cristóbal Curkovic, Fabián Montecino, Christopher Holmes, Juan Enrique Tichauer, Eric Acuña, Marjorie Castro, Francisco Osorio-Barrios, Priscilla Cortes, Claudia Oyanadel, Rodrigo Pacheco, Rodrigo Naves, Andrea Soza and Alfonso González.
  “GALECTIN-8 AS A NEW ANTIGEN WITH EARLY PROGNOSTIC VALUE IN MULTIPLE SCLEROSIS AND IMMUNOSUPPRESSIVE ACTIVITY IN AUTOINMUNE ENCEPHALOMYELITIS IN MICE”.
  PLoS ONE. 12(6): e0177472. 2017

• María Elvira Balcells, Patricia García, Camila Tiznado, Luis Villarroel, Natalia Scioscia, Camila Carvajal, Francesca Zegna-Ratá, Mariluz Hernández, Paulina Meza, Luis F. González, Carlos Peña, Rodrigo Naves*.
  “ASSOCIATION OF VITAMIN D DEFICIENCY, SEASON OF THE YEAR, AND LATENT TUBERCULOSIS INFECTION AMONG HOUSEHOLD CONTACTS”.
  PLoS ONE. 12(4): e0175400. 2017

• Payton Amelia Ottum, Gabriel Arellano, Lilian Reyes, Mirentxu Iruretagoyena and Rodrigo Naves*.
  “OPPOSING ROLES OF INTERFERON-GAMMA ON CELLS OF THE CENTRAL NERVOUS SYSTEM IN AUTOIMMUNE NEUROINFLAMMATION”. 
  Frontiers in Immunology. 6: 539. 2015

• M. Iruretagoyena, D. Hirigoyen, R. Naves and P.I. Burgos.
  “IMMUNE RESPONSE MODULATION BY VITAMIN D: ROLE IN SYSTEMIC LUPUS ERYTHEMATOSUS”.
  Frontiers in Immunology. 6: 513. 2015

• Gabriel Arellano, Payton Amelia Ottum, Lilian Reyes, Paula Burgos and Rodrigo Naves*.
  “STAGE-SPECIFIC ROLE OF INTERFERON-GAMMA IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS AND MULTIPLE SCLEROSIS”.
  Frontiers in Immunology. 6: 492. 2015

• Rafael Fenutria, Vanesa G. Martínez, Inés Simoes, Jorge Postigo, Víctor Gil, Mario Martínez-Florensa, Jordi Sintes, Rodrigo Naves, Kevin A. Cashman,  José Alberola-Ila, Manel Ramos-Casals, Gloria Soldevila, Chander Raman, Jesús Merino, Ramón Merino, Pablo Engel and Francisco Lozano.
  “TRANSGENIC EXPRESSION OF SOLUBLE HUMAN CD5 ENHANCES EXPERIMENTALLY INDUCED AUTOIMMUNE AND ANTI-TUMORAL IMMUNE RESPONSES”.
  PLoS ONE. 9(1):e84895. 2014

• Rodrigo Naves*, Simer P. Singh, Kevin S. Cashman, Amber L. Rowse, Robert C. Axtell, Lawrence Steinman, John D. Mountz, Chad Steele, Patrizia De Sarno and Chander Raman.
  “THE INTERDEPENDENT, OVERLAPPING AND DIFFERENTIAL ROLES OF TYPE I AND TYPE II INTERFERONS IN THE PATHOGENESIS EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS”.
  The Journal of Immunology. 191(6): 2967. 2013

Laboratorio Dr L. Carreño:

• Chennamadhavuni D, Saavedra-Avila NA, Carreño LJ, Guberman-Pfeffer MJ, Arora P, Yongqing T, Pryce R, Koay HF, Godfrey DI, Keshipeddy S, Richardson SK, Sundararaj S, Lo JH, Wen X, Gascón JA, Yuan W, Rossjohn J, Le Nours J, Porcelli SA, Howell AR. Dual Modifications of α-Galactosylceramide Synergize to Promote Activation of Human Invariant Natural Killer T Cells and Stimulate Anti-tumor Immunity. Cell Chem Biol. 2018;25(5):571-584.e8.

• Rey-Jurado E, Tapia F, Muñoz-Durango N, Lay MK, Carreño LJ, Riedel CA, Bueno SM, Genzel Y, Kalergis AM. Assessing the Importance of Domestic Vaccine Manufacturing Centers: An Overview of Immunization Programs, Vaccine Manufacture, and Distribution. Front Immunol. 2018;9:26.

• Rohatgi S, Nakouzi A, Carreño LJ, Slosar-Cheah M, Kuniholm MH, Wang T, Pappas PG, Pirofski LA. Antibody and B Cell Subset Perturbations in Human Immunodeficiency Virus-Uninfected Patients With Cryptococcosis. Open Forum Infect Dis. 2018;5(1):ofx255.

• Schäfer C, Ascui G, Ribeiro CH, López M, Prados-Rosales R, González PA, Bueno SM, Riedel CA, Baena A, Kalergis AM, Carreño LJ. Innate immune cells for immunotherapy of autoimmune and cancer disorders. Int Rev Immunol. 2017;36(6):315-337.

• Mordorski B, Costa-Orlandi CB, Baltazar LM, Carreño LJ, Landriscina A, Rosen J, Navati M, Mendes-Giannini MJS, Friedman JM, Nosanchuk JD, Friedman AJ. Topical nitric oxide releasing nanoparticles are effective in a murine model of dermal Trichophyton rubrum dermatophytosis. Nanomedicine. 2017;13(7):2267-2270.

• Carreño LJ, Prados-rosales R, López M, Baena A, González PA. Targeting Innate Immune Cells for Immunotherapy. J Immunol Res. 2017;2017:4271384.

• Saini NK, Baena A, Ng TW, Venkataswamy MM, Kennedy SC, Kunnath-Velayudhan S, Carreño LJ, Xu J, Chan J, Larsen MH, Jacobs WR Jr, Porcelli SA. Suppression of autophagy and antigen presentation by Mycobacterium tuberculosis PE_PGRS47. Nat Microbiol. 2016;1(9):16133.

• Prados-Rosales R, Carreño LJ, Weinrick B, Batista-Gonzalez A, Glatman-Freedman A, Xu J, Chan J, Jacobs WR Jr, Porcelli SA, Casadevall A. The Type of Growth Medium Affects the Presence of a Mycobacterial Capsule and Is Associated With Differences in Protective Efficacy of BCG Vaccination Against Mycobacterium tuberculosis. J Infect Dis. 2016;214(3):426-37.

• Carreño LJ, Saavedra-Ávila NA, Porcelli SA. Synthetic glycolipid activators of natural killer T cells as immunotherapeutic agents. Clin Transl Immunology. 2016;5(4):e69.

• Riquelme SA, Carreño LJ, Espinoza JA, Mackern-Oberti JP, Alvarez-Lobos MM, Riedel CA, Bueno SM, Kalergis AM. Modulation of antigen processing by haem-oxygenase 1. Implications on inflammation and tolerance. Immunology. 2016;149(1):1-12.

Laboratorio  Dr F. Salazar:

• González FE, et al. Proteomic Identification of Heat Shock-Induced  Danger Signals in a Melanoma Cell Lysate Used in Dendritic Cell-Based Cancer Immunotherapy. J Immunol Res. 2018 Mar 18;2018:3982942. doi: 10.1155/2018/3982942.

• García-Salum T, et al. Molecular signatures associated with tumor-specific immune response in melanoma patients treated with dendritic cell-based immunotherapy. Oncotarget. 2018 Mar 30;9(24):17014-17027. doi: 10.18632/oncotarget.24795.

• Rojas-Sepúlveda D, et al. Tumor lysate-based vaccines: on the road to immunotherapy for gallbladder cancer. Cancer Immunol Immunother. 2018 Mar 29. doi: 10.1007/s00262-018-2157-5.

• Fluxá P, et al. High CD8(+) and absence  of Foxp3(+) T lymphocytes infiltration in gallbladder tumors correlate with prolonged patients survival. BMC Cancer. 2018 Mar 2;18(1):243. doi: 10.1186/s12885-018-4147-6.

• Araya HF, et al. Expression of the  ectodomain-releasing protease ADAM17 is directly regulated by the osteosarcoma and bone-related transcription factor RUNX2. J Cell Biochem. 2018 Jun 19. doi: 10.1002/jcb.26832.

• Gálvez-Cancino F, et al. Vaccination-induced skin-resident memory CD8(+) T cells mediate strong protection against cutaneous melanoma. Oncoimmunology. 2018 Mar 19;7(7):e1442163. doi: 10.1080/2162402X.2018.1442163.

• Palacios M, et al. Antitumor activity and carrier properties of novel hemocyanins coupled to a mimotope of GD2 ganglioside. Eur J Med Chem. 2018 Apr 25;150:74-86. doi: 10.1016/j.ejmech.2018.02.082.

• Oyarce C, et al. Caveolin-1 Expression Increases upon Maturation in Dendritic Cells and Promotes Their Migration to Lymph Nodes Thereby Favoring the Induction of CD8(+) T Cell Responses. Front Immunol. 2017 Dec 13;8:1794. doi: 10.3389/fimmu.2017.01794.

• Vega OA, et al. Wnt/β-Catenin Signaling Activates Expression of the Bone-Related Transcription Factor RUNX2 in Select Human Osteosarcoma Cell Types. J Cell Biochem. 2017 Nov;118(11):3662-3674. doi: 10.1002/jcb.26011.

• Pizarro-Bauerle J, et al. Molluskan Hemocyanins Activate the Classical Pathway of the Human Complement System through Natural Antibodies. Front Immunol. 2017 Feb 24;8:188. doi: 10.3389/fimmu.2017.00188.

• Gleisner MA, et al. Mind the  Gaps in Tumor Immunity: Impact of Connexin-Mediated Intercellular Connections. Front Immunol. 2017 Sep 1;8:1067. doi: 10.3389/fimmu.2017.01067.

• Torres A, et al. Adenosine A3 receptor elicits chemoresistance mediated by multiple resistance-associated protein-1 in human glioblastoma stem-like cells. Oncotarget. 2016 Oct 11;7(41):67373-67386. doi: 10.18632/oncotarget.12033.

• Pérez CA, et al. Dendritic cell chimerism in oral mucosa of transplanted patients affected by graft-versus-host disease. J Oral Pathol Med. 2016 Feb;45(2):127-35. doi: 10.1111/jop.12338.

• Tittarelli A, et al. Overexpression of connexin 43 reduces melanoma proliferative and metastatic capacity. Br J Cancer.  2015 Jul 14;113(2):259-67. doi: 10.1038/bjc.2015.162.

• Osorio F, et al. Role of Dendritic Cells in the Induction of Lymphocyte Tolerance. Front Immunol. 2015 Oct 20;6:535. doi: 10.3389/fimmu.2015.00535.

• Mackern-Oberti JP, et al. Role of dendritic cells in the initiation, progress and modulation of systemic autoimmune diseases. Autoimmun Rev. 2015 Feb;14(2):127-39. doi: 10.1016/j.autrev.2014.10.010.

• Tittarelli A, et al. The Selective Degradation of Synaptic Connexin 43 Protein by Hypoxia-induced Autophagy Impairs  Natural Killer Cell-mediated Tumor Cell Killing. J Biol Chem. 2015 Sep 25;290(39):23670-9. doi: 10.1074/jbc.M115.651547.

• Tittarelli A, et al. Gap junction intercellular communications regulate NK cell activation and modulate NK cytotoxic capacity. J Immunol. 2014 Feb 1;192(3):1313-9. doi: 10.4049/jimmunol.1301297.

• González FE, et al. Tumor cell lysates as immunogenic sources for cancer vaccine design. Hum Vaccin Immunother. 2014;10(11):3261-9. doi: 10.4161/21645515.2014.982996.

• González FE, et al. Melanoma cell lysate induces CCR7 expression and in vivo migration to draining lymph nodes of therapeutic human dendritic cells. Immunology. 2014 Jul;142(3):396-405. doi: 10.1111/imm.12264.

• Durán-Aniotz C, et al. The immunological response and post-treatment survival of DC-vaccinated melanoma patients are associated with increased Th1/Th17 and reduced Th3 cytokine responses. Cancer Immunol Immunother. 2013 Apr;62(4):761-72. doi: 10.1007/s00262-012-1377-3.

• Salazar-Onfray F, Pereda C, Reyes D, López MN. TAPCells, the Chilean dendritic cell vaccine against melanoma and prostate cancer. Biol Res. 2013;46(4):431-40. doi: 10.4067/S0716-97602013000400014.

• González FE, et al. Melanocortin 1 Receptor-derived peptides are efficiently recognized by cytotoxic T lymphocytes from melanoma patients. Immunobiology. 2014 Mar;219(3):189-97. doi: 10.1016/j.imbio.2013.10.002.

• Reyes D, et al. Tumour cell lysate-loaded dendritic cell vaccine induces biochemical and memory immune response in castration-resistant prostate cancer patients. Br J Cancer. 2013 Sep  17;109(6):1488-97. doi: 10.1038/bjc.2013.494.

Laboratorio Dra C. Hager Ribeiro:

• SCHAFER, Carolina, ASCUI, Gabriel, RIBEIRO, Carolina Hager, LÓPEZ, M., PRADOS-ROSALES, R., GONZÁLEZ, P.A., BUENO, S., RIEDEL, C.A., BAENA, A., KALERGIS, A.M., and CARREÑO, L.J. Innate immune cells for immunotherapy of autoimmune and cancer disorders. International Reviews of Immunology, 36(6):315-337, 2017

• GARRIDO-TAPIA, Macarena, HERNÁNDEZ, Carolina, ASCUI, Gabriel, KRAMM, Karina, MORALES, Marcela, GÁRATE, Valentina, RIBEIRO, ZÚÑIGA, Roberto, BUSTAMANTE, Marco, AGUILLÓN, Juan Carlos, CATALÁN, Diego, RIBEIRO, Carolina Hager, and MOLINA, María Carmen. STAT3 inhibition by STA21 increases cell surface expression of MICB and the release of soluble MICB by gastric adenocarcinoma cells. Immunobiology, 2985(17) 30091-8, 2017

• RIBEIRO, Carolina Hager, KRAMM, Karina, BUSTAMANTE, Marco, ZÚÑIGA, Roberto, COLLAZO, Norberto, GARRIDO-TAPIA, Macarena, HERNÁNDEZ, Carolina, SOTELO, Pablo Hernán, CATALÁN, Diego, AGUILLÓN, Juan Carlos, and MOLINA, María Carmen. Clinical Significance of tumor expression of major histocompatibility complex class I-related chains A and B (MICA/B) in gastric cancer patients. Oncology Reports, 35(3), 2016

• SERRANO, Antonio, MENARES-CASTILLO, Evelyn, GARRIDO-TAPIA Macarena, RIBEIRO, Carolina Hager, HERNÁNDEZ, Carolina, MENDOZA-NARANJO, Ariadna, GATICA-ANDRADES, Marcela, VALENZUELA-DÍAZ, Rodrigo, ZÚÑIGA, Roberto, LÓPEZ, Mercedes N, SALAZAR-ONFRAY, Flavio, AGUILLÓN, Juan Carlos, and MOLINA, María Carmen. Interleukin 10 decreases MICA expression on melanoma cell surface. Immunology and Cell Biology, 89(3), 2010

Laboratorio  Dr D. Catalan:

• Paulina García-González, Katina Schinnerling, Alejandro Sepúlveda-Gutiérrez, Jaxaira Maggi, Ahmed Mehdi, Hendrik Nel, Bárbara Pesce, Milton Larrondo, Octavio Aravena, María Carmen Molina, Diego Catalán, Ranjeny Thomas, Ricardo Verdugo, Juan Carlos Aguillón. Dexamethasone and Monophosphoryl Lipid A induce a distinctive profile on monocyte-derived dendritic cells through transcriptional modulation of genes associated with essential processes of the immune response. Frontiers in Immunology 8:1350. 2017.

• Macarena Garrido-Tapia, Carolina J. Hernández, Gabriel Ascui, Karina Kramm, Marcela Morales, Valentina Gárate, Roberto Zuñiga, Marco Bustamante, Juan Carlos Aguillón, Diego Catalán, Carolina H. Ribeiro, María Carmen Molina. STAT3 inhibition by STA21 increases cell surface expression of MICB and the release of soluble MICB by gastric adenocarcinoma cells. Immunobiology 222(11):1043-1051. 2017.

• Katina Schinnerling, Juan Carlos Aguillón, Diego Catalán, Lilian Soto. The role of IL-6 signaling and its therapeutic blockage in skewing the T cell balance in rheumatoid arthritis. Clinical and Experimental Immunology. 189(1):12-20. 2017.

• Octavio Aravena, Ashley Ferrier, Madhvi Menon, Claudia Mauri, Juan Carlos Aguillón, Lilian Soto, Diego Catalán. TIM-1 defines a human regulatory B cell population that is altered in frequency and function in systemic sclerosis patients. Arthritis Research and Therapy. 19(1):8. 2017.

• María Teresa Ciudad, Nicoletta Sorvillo, Floris P. van Alphen, Diego Catalán, Alexander B Meijer, Jan Voorberg, Dolores Jaraquemada. Analysis of the HLA-DR peptidome from human dendritic cells reveals high affinity repertoires and nonconventional pathways of peptide generation. Journal of Leukocyte Biology. 101(1):15-27. 2017.

• Paulina García-González, Katina Schinnerling, Alejandro Sepúlveda-Gutiérrez, Jaxaira Maggi, Lorena Hoyos, Rodrigo Morales, Ahmed Mehdi, Hendrik Nel, Lilian Soto, Bárbara Pesce, María Carmen Molina, Miguel Cuchacovich, Milton Larrondo, Óscar Neira, Diego Catalán, Catharien Hilkens, Ranjeny Thomas, Ricardo Verdugo, Juan Carlos Aguillón. Treatment with dexamethasone and monophosphoryl lipid A removes disease-associated transcriptional signatures in monocyte-derived dendritic cells from rheumatoid arthritis patients and confers tolerogenic features. Frontiers in Immunology 7:458. 2016.

• Paulina García-González, Gabriela Ubilla-Olguín, Diego Catalán, Katina Schinnerling, Juan Carlos Aguillón. Tolerogenic dendritic cells for reprogramming of lymphocyte responses in autoimmune diseases. Autoimmunity Reviews 15(11):1071-1080. 2016.

• Jaxaira Maggi, Katina Schinnerling, Bárbara Pesce, Catharien Hilkens, Diego Catalán, Juan Carlos Aguillón. Dexamethasone and monophosphoryl lipid A-modulated dendritic cells promote antigen-specific tolerogenic properties on naive and memory CD4+ T cells. Frontiers in Immunology 7:359. 2016.

• Karina Pino-Lagos, Diego Catalán. Editorial: Searching for immune tolerance manipulating new molecules and exploiting new concepts on lymphocyte biology. Frontiers in Immunology 7:27. 2016.

• Carolina Hager Ribeiro, Karina Kramm, Felipe Gálvez-Jirón, Víctor Pola, Marco Bustamante, Héctor R. Contreras, Andrea Sabag, Macarena Garrido-Tapia, Carolina J. Hernández, Roberto Zúñiga, Norberto Collazo, Pablo H Sotelo, Camila Morales, Luis Mercado, Diego Catalán, Juan Carlos Aguillón, María Carmen Molina. Clinical significance of tumor expression of major histocompatibility complex class I-related chains A and B (MICA/B) in gastric cancer patients. Oncology Reports 35(3): 1309-1317. 2016.

• Lilian Soto, Diego Catalán, Juan Carlos Aguillón, Miguel Cuchacovich. How we can improve the predictive value of prognostic biomarkers in rheumatoid arthritis. International Journal of Clinical Rheumatology. 10 (4) 207-209. 2015.

• Lilian Soto, Ashley Ferrier, Octavio Aravena, Elianet Fonseca, Jorge Berendsen, Andrea Biere, Daniel Bueno, Verónica Ramos, Juan Carlos Aguillón, Diego Catalán*. Systemic sclerosis patients present alterations in the expression of molecules involved in B-cell regulation. Frontiers in Immunology. 6:496. 2015.

• Jaxaira Maggi, Carolina Schafer, Gabriela Ubilla-Olguín, Diego Catalán, Katina Schinnerling, Juan Carlos Aguillón. Therapeutic potential of hyporesponsive CD4+ T cells in autoimmunity. Frontiers in Immunology. 6:488. 2015.

• Katina Schinnerling, Lilian Soto, Paulina García-González, Diego Catalán, Juan C. Aguillón. Skewing dendritic cell differentiation towards a tolerogenic state for recovery of tolerance in rheumatoid arthritis. Autoimmunity Reviews. 14(6):517-527. 2015. ISI-IF: 8.490.

• Javier Campos-Acuña, Francisco Pérez, Edgar Narváez, Mauricio Campos-Mora, Tania Gajardo, Diego Catalán, Juan C. Aguillón, Karina Pino-Lagos. Rapamycin-conditioned dendritic cells activated with monophosphoryl lipid-A promote allograft acceptance in vivo. Immunotherapy. 7(2):101-10. 2015. ISI-IF: 2.083.

• Mauricio Campos-Mora, Rodrigo Morales, Francisco Pérez, Tania Gajardo, Javier Campos, Diego Catalán, Juan Carlos Aguillón, Karina Pino-Lagos. Neuropilin-1+ regulatory T cells promote skin allograft survival and modulate effector CD4+ T cells phenotypic signature. Immunology and Cell Biology. 93(2):113-9. 2015.

• Miguel Cuchacovich, Daniel Bueno, Rodrigo Carvajal, Nicolás Bravo, Juan Carlos Aguillón, Diego Catalán, Lilian Soto. Clinical parameters and biomarkers for anti-TNF treatment prognosis in rheumatoid arthritis patients. Clinical Rheumatology. 33(12):1707-14. 2014.

• Alejandro Escobar, María Antonieta Guzmán, Mercedes López, Bárbara Pesce, Adam Aguirre, Rodrigo González, Diego Catalán, Claudio Acuña-Castillo, Milton Larrondo, Juan Carlos Aguillón. Tolerogenic dendritic cells derived from donors with natural rubber latex allergy modulate allergen-specific T-cell responses and IgE production. PLoS ONE. 9(1): e85930. 2014.

Laboratorio  Dr A. Ferreira:

• Pujol M.,  Castillo F., Alvarez C., Rojas C., Borie C., Ferreira A. y Vernal R.  2017.  Variability in the Response of Canine and Human Dendritic Cells Stimulated with Brucella canis.  Veterinary Research.  48:72. DOI: 10.1186/S13567-017-0476-8. Francia. Biomed. Central Ltd. ISSN: 0928-4249.

• Ramírez-Toloza G. and Ferreira A. 2017. Trypanosoma cruzi Evades the Complement System as an Efficient Strategy to Survive in the Mammalian Host: The Specific Roles of Host/Parasite Molecules and Trypanosoma cruzi Calreticulin. Front. Microbiol., 8: 1664.  01 September 2017. Netherlands, ELSEVIER BV. ISSN: 0379-1135.

• Sosoniuk-Roche E., Vallejos G., Aguilar-Guzmán L., Pizarro-Bäuerle J., Weinberger K., Rosas C., Valck C., Michalak M., Ferreira A. 2017. Exogenous Calreticulin, Incorporated onto non-Infective Trypanosoma cruzi Epimastigotes, Promotes their Internalization into Mammal Host Cells. Immunobiology 222 (3), 529-535.  Germany: Elsevier Gmby, Urban Y Fisher. ISSN: 0171-285.

• Vera CA., Oróstica L., Gabler F., Ferreira A., Selman A., Vega M. Romero CA. 2017. The Nerve Growth Factor Alters Calreticulin Translocation from the Endoplasmic Reticulum to the Cell Surface and its Signaling Pathway in Epithelial Ovarian Cancer Cells. International Journal of Oncology. 50(4): 1261-1270. Received November 2, 2016; Accepted February 20, 2017. DOI: 10.3892/ijo.2017.3892. GREECE. Spandidos Publ Ltd. ISSN: 1019-6439.

• Pizarro-Bauerle J., Maldonado I., Sosoniuk-Roche E., Vallejos G., López M.N, Salazar-Onfray F., Aguilar-Guzmán L., Valck C., Ferreira A., Becker M.I. 2017. Molluskan Hemocyanins Activate the Classical Pathway of the Human Complement System through Natural Antibodies. Frontiers in Immunology 24: 8: 188. Swtzerland.  Frontiers Media S.A. ISSN: 1664-3224.

• Weinberger K., Collazo N., Aguillon J.C., Molina M.C., Rosas C., Peña Jm, Pizarro J., Maldonado I., Cattán P., Apt W., Ferreira A. 2016. Triatoma infestans Calreticulin: Gene Cloning and Expression of a Main Domain that Interacts with the Host Complement System. American Journal of Tropical Medicine and Hygiene, 96(2): 295-303.  USA. AmerMER SOC. Trop. Med. Y Hygiene. ISSN: 0002-9637.

• Ramírez-Toloza G., Abello P., Ferreira A. 2016. Is the Antitumor Property of Trypanosoma cruzi Infection Mediated by its Calreticulin? Frontiers in Immunology. 8: 1667.   Suiza. Editorial Frontiers Media SA. Publicado. ISSN 1664-3224.

• Abello-Cáceres P., Pizarro-Bauerle J., Rosas C, Maldonado I., Aguilar-Guzmán L., González C., Ramírez G., Ferreira J., Ferreira A. 2016. Does Native Trypanosoma cruzi Calreticulin Mediate Growth Inhibition of a Mammary Tumor During Infection? BMC Cáncer. 6:731. Inglaterra. Editorial Biomed Central Ltd. Publicado. ISSN 1471-2407.

• Moreau C., Cioci G., Iannello M., Laffly E., Chouquet A., Ferreira A., Thielens NM., Gaboriaud C. 2016. Structures of Parasite Calreticulins Provide Insights into their Flexibility and Dual Carbohydrate/peptide-binding Properties. IUCRJ.  3(PT6): 408-419. Inglaterra. Editorial Int Union Crystallography. Publicado. ISSN 2052-2525.

• Chacón F., Bacigalupo A., Quiroga JF., Ferreira A, Cattan PE., Ramírez-Toloza G. 2016. Feeding Profile A of Mepraia spinolai, a Sylvatic Vector of Chagas disease in Chile. Acta Tropica. 162: 171-3. Netherlands. Editorial Elsevier Science Bv. Publicado. ISSN 1873-6254.

• Arias J. I.,  Sepúlveda C., Bravo P., Hamilton-West C., Maldonado I., Ferreira A. 2015. Comparative Effect of Human and Trypanosoma cruzi Calreticulin in Wound Healing. Journal of Tissue Engineering and Regenerative Medicine. 9:41-54. Inglaterra. Editorial: John Wiley & Sons Ltd. Issn 1932-6254.

• Ramírez-Toloza G., Aguilar-Guzmán L., Valck C., Abello P. and Ferreira A., 2015. Is it all that Bad When Living with an Intracellular Protozoan? The Role of Trypanosoma cruzi Calreticulin In Angiogenesis and Tumor Growth. Frontiers In Oncology. 4:1-6. Suiza. Editorial Frontiers Media SA. Publicado. ISSN 2234-943X.

• González A., Valck C., Sánchez G., Härtel S.,  Mansilla J., Ramírez G., Fernández M.S., Arias J.L., Galanti N.  and Ferreira A. 2015. Trypanosoma cruzi Calreticulin Topographical Variations in Parasites Infecting Murine Macrophages. American Journal of Tropical Medicine and Hygiene. USA. Editorial Amer Soc Trop Med & Hygiene. Publicado. ISSN 1476-1645.

• Sánchez-Valdéz F.J., Pérez Brandán C., Ferreira A., Basombrío M.A. 2015. Gene-Deleted Live-Attenuated Parasites as Vaccines to Protect Against Chagas Disease. Expert Reviews of Vaccines. 14: (5): 681-697. Inglaterra. Editorial Taylor & Francis Ltd. Publicado. ISSN 1476-0584.

• Ribeiro C. H., Lynch N. J., Stover C. M., Mohammed Ali Y., Valck C., Noya Leal F., Schwaeble W. J., Ferreira A., 2015. Deficiency in Mannose-Binding Lectin-Associated Serine Protease-2 Does not Provide an Immunological Disadvantage to Control Trypanosoma cruzi Infection.

• American Journal of Tropical Medicine and Hygiene. 92:320-324. USA. Editorial Amer Soc Trop Med & Hygiene. Publicado. ISSN 1476-1645.

• E. Sosoniuk, G. Vallejos, H. Kenawy, C. Gaboriaud, N. Thielens, T. Fujita, W. Schwaeble, C. Valck, A. Ferreira, 2014. Trypanosoma cruzi Calreticulin Inhibits The Complement Lectin Pathway Activation by Direct Interaction with L-Ficolin. Molecular Immunology, 60: 80-85.

• L. Aguilar-Guzmán, L. Lobos-González, C. Rosas, G. Vallejos, C. Falcón, E. Sosoniuk, F. Coddou, L.  Leyton, D. Lemus, A.F.G. Quest, A. Ferreira. 2014.  Human Survivin and Trypanosoma cruzi Calreticulin Act in Synergy Against a Murine Melanoma in vivo. PLoS ONE, 9 (4) DOI:10.1371/Journal.pone.0095457.

• F. Sánchez-Valdéz, C. Pérez, G. Ramirez, A. Uncos, M. Zago, R. Cimino, R. Cardozo, D. Marco, M. Á.  Basombrío and A. Ferreira. 2014. A Monoallelic Deletion Of The TcCRT Gene Increases The Attenuation of a Cultured Trypanosoma cruzi Strain, Protecting Against an in vivo Virulent Challenge. PLoS Neglected Tropical Diseases 8(2): e2696.

• F. Medina, S. Quintremil, C. Alberti, A. Barriga, L. Cartier, J. Puente, E. Ramírez, A. Ferreira, Y. Tanaka,  M. A. Valenzuela. 2014. Tax Posttranslational Modifications and Interaction with Calreticulin in MT-2 Cells and Human T Cell Lymphotropic Virus Type-I-Associated Myelopathy/Tropical Spastic Paraparesis Patiens. AIDS Research and Human Retroviruses.  DOI: 10.1089/aid. 2013.0036.

• C. Rosas, M. Sinning, F. Ginesta, A. Ferreira, M. Fuenzalida1, D. Lemus, C. Rosas. 2014.  Celecoxib Decreases Growth and Angiogenesis and Promotes Apoptosis in a Tumor Cell Line Resistant to Chemotherapy Biological Research. 47: 1-9.

• C. Castillo, G. Ramírez, C. Valck, L. Aguilar, I. Maldonado, C. Rosas, N. Galanti, U. Kemmerling, A. Ferreira. 2013. The Interaction of Classical Complement Component C1 with Parasite and Host Calreticulin Mediates Trypanosoma cruzi Infection of Human Placenta. PLoS Neglected Tropical Diseases 7(8): e2376.

• Sánchez, C.  Perez, P. Zago, C. Labriola, M. Basombrío, A. Ferreira. 2013. Trypanosoma cruzi Carrying a Monoallelic Deletion of the Calreticulin (TcCRT) Gene Are Susceptible to Complement Mediated Killing and Defective in Their Metacyclogenesis. Molecular Immunology 53(3): 198-205.

Laboratorio  Dra M. Hermoso:

• Mauricio Olivares-Morales, Marjorie De la Fuente, Karen Dubois, Daniela Parada, David Diaz-Jiménez, Alejandro Torres-Riquelme, Xiaojiang Xu, Nayaret Chamorro, Rodrigo Naves, Maria-Julieta Gonzalez, Rodrigo Quera, Carolina Figueroa, John Cidlowski, Roberto Vidal, Marcela A. Hermoso. Glucocorticoids Impair Phagocytosis and Inflammatory Response Against Crohn’s Disease-Associated Adherent-Invasive Escherichia coli. Front Immunol. 2018 May 16;9:1026. doi: 10.3389/fimmu.2018.01026. eCollection 2018. PMID: 29867993.

• Dubois-Camacho K, Ottum PA, Franco-Muñoz D, De la Fuente M, Torres-Riquelme A, Díaz-Jiménez D, Olivares-Morales M, Astudillo G, Quera R, Hermoso MA. Glucocorticosteroid therapy in inflammatory bowel diseases: From clinical practice to molecular biology. World J Gastroenterol. 2017 Sep 28;23(36):6628-6638. doi: 10.3748/wjg.v23.i36.6628.

• David Díaz-Jiménez, Lucía Núñez, Marjorie De la Fuente, Karen Dubois, Alejandro Torres, Paulina García-González, Jonás Chnaiderman, Hugo Sepúlveda, Martín Montecino, Anna Vossenkaemper, Thomas T. MacDonald, Daniela Simian, María-Julieta González, Rodrigo Quera, Marcela A. Hermoso. A functional IL1RL1 variant regulates corticosteroid-induced sST2 expression in ulcerative colitis. Scientific Rep 2017 Aug 31;7(1):10180. doi: 10.1038/s41598-017-10465-0.

• De La Fuente M, Chahuán I, Gutiérrez R, Díaz-Jiménez D, Olivares M, Vidal R, Simian D, Figueroa C, Quera R, Hermoso MA. [Presence of intracellular Escherichia coli in patients with inflammatory bowel disease]. Rev Med Chil. 2017 Sep;145(9):1129-1136. doi: 10.4067/s0034-98872017000901129. Spanish.

• Sandra Cespedes, Waleska Saitz, Felipe Del Canto, Marjorie De la Fuente, Rodrigo Quera, Marcela Hermoso, Raul Muñoz, Daniel Ginard, Sam Khorrami, Jorge Giron, Ramon Rosello Mora, Roberto Mauricio Vidal. Genetic diversity and virulence determinants of Escherichia coli strains isolated from patients with Crohn’s disease in Spain and Chile. Frontiers in Microbiology, in press.

• David Díaz-Jiménez, Marjorie de La Fuente, Karen Dubois, Glauben Landskron, Janitza Fuentes, Tamara Perez, María Julieta González, Daniela Simian, Marcela A. Hermoso, Rodrigo Quera. Soluble ST2 is a sensitive clinical marker of ulcerative colitis evolution. Journal BMC Gastroenterol. 2016 Aug 26;16:103. doi: 10.1186/s12876-016-0520-6.}De la Fuente M, MacDonald TT, Hermoso MA. The IL-33/ST2 axis: Role in health and disease. Cytokine Growth Factor Rev. 2015 Dec; 26(6):615-23. doi: 10.1016/j.cytogfr.2015.07.017. Epub 2015 Jul 28.

• Vidal R, Ginard D, Khorrami S, Mora-Ruiz M, Munoz R, Hermoso M, Díaz S, Cifuentes A, Orfila A, Rosselló-Móra R. Crohn associated microbial communities associated to colonic mucosal biopsies in patients of the western Mediterranean. Syst Appl Microbiol. 2015 Sep;38(6):442-52. doi: 10.1016/j.syapm.2015.06.008. Epub 2015 Jul 22.

• Patricia Langjahr, David Díaz-Jiménez, Marjorie De la Fuente, Estefhany Rubio, Douglas Golenbock, Francisca C. Bronfman, Rodrigo Quera, María-Julieta González, Marcela A. Hermoso. Metalloproteinase-dependent TLR2 ectodomain shedding is involved in soluble toll-like receptor 2 (sTLR2) production. PLoS One. 2014 Dec 22;9(12):e104624. doi: 10.1371/journal.pone.0104624. eCollection 2014.

• Glauben Landskron, Marjorie De la Fuente, Peti Thuwajit, Chanitra Thuwajit and Marcela A. Hermoso. Chronic inflammation and cytokines in the tumor microenvironment. Journal Immunology Research 2014, http://dx.doi.org/10.1155/2014/149185.

• De la Fuente M, Franchi L, Araya D, Díaz-Jiménez D, Olivares M, Alvarez-Lobos M, Golenbock D, González MJ, López-Kostner F, Quera R, Núñez G, Vidal R, Hermoso MA. Escherichia coli isolates from inflammatory bowel diseases patients survive in macrophages and activate NLRP3 inflammasome. Int J Med Microbiol. 2014 May; 304(3-4): 384-92. doi: 10.1016/j.ijmm.2014.01.002.